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MACROCYCLIC COMPLEXES BIPYRIDINE MOETIY PDF

complex interactive process of activation and inhibition within and between levels 2,2’bipyridine-4,4′-dicarboxylic acid and L’ is 2,2′-bipyridine. One of the first with Ruthenium dyes, with the moetiy 2-(hexylthio)methylthiophene, the dye . Porphyrins consist on a tetra pyrrole macrocycle composed of four modified.

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Such methods comprise, but are not limited to, receptor autoradiography Reubi et al. Classification of chemical bonds based on topological analysis of electron localization functions. The conjugate of any one of embodiments 1 to 36, wherein the first adapter moiety AD1 mediates linkage to the first targeting moiety TM1 and to an adjacent moiety, wherein the adjacent moiety is selected from the group comprising linker moiety LM, building block moiety [X]a, branching moiety Y, building block moiety [Z]b, second adapter moiety AD2 and second targeting moiety TM2.

The conjugate of any one of embodiments 37 to 38, wherein the first adapter moiety AD1, preferably prior to forming any linkage, is of the following structure: Set,18, ; Cescato et al, J. No part of this macrovyclic can be reproduced, transferred, distributed or stored in any format without the prior written permission of More information.

Email Reminder Subscribers must have a valid. HotSpot Printing App supports: The conjugate of embodiment 40, wherein the linkage is individually and independently selected from the group comprising an bioyridine linkage, a sulfonamide linkage, a urea linkage, a thioether linkage, an ether linkage, a carbamate linkage, an amine linkage, a triazole linkage, an oxime linkage, a hydrazone linkage, a disulfide linkage, a pyrazine linkage and a dihydropyrazine linkage.

The atoms boron through neon and hydrogen. Depending on the characteristics of the first targeting moiety of the conjugate of the invention in.

ScreenBeam Configurator for Windows 8. In a further embodiment of the conjugate of the invention the antibody is a human antibody, a humanized antibody, a chimeric antibody, a sub-primate antibody a murine antibody or an antibody from other species, i.

It s all here. Imaging,30, ; and Janssen et ah, Cancer Biother.

The conjugate of any one of embodiments 1 to 25, preferably any one of embodiments 20 to 25, wherein the first targeting moiety and the second targeting moiety are separated by 4 to covalent bonds, preferably 5 to covalent bonds, more preferably 10 to 40 covalent bonds.

The conjugate of any one of embodiments 1 macrocylcic 39, wherein the second adapter moiety AD2 mediates linkage to the second targeting moiety TM2 and to an adjacent moiety, wherein the adjacent moiety is selected from the group comprising linker moiety LM, building block moiety [Z]b, branching moiety Y, building block moiety [X]a, first adapter moiety AD1 and first targeting moiety TM1.

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The conjugate of embodiment 79, wherein the disease is a disease involving a target targeted by the first targeting moiety TM1 or by the scond targeting moiety TM2, preferably the disease is one involving neurotensin receptor, more preferably moteiy disease is a disease involving neurotensin receptor 1.

The conjugate of embodiment 46, wherein the adapter moiety mediates the linkage between branching moiety [Y] and the effector moiety EM. The conjugate of embodiment 76, wherein the glycoside is a N-glycoside, C-glycoside, 0-gylcoside or an S-glycoside, preferably the glycoside is N-glycoside.

Strong correlations in actinide redox reactions. It is within the present invention that a target to which the further targeting moiety of the conjugate of the invention is capable of binding, is a target that is expressed in an indication, preferably a tumor indication, whereby such target can be identified by methods known in the art.

In an embodiment and as preferably used herein, a diagnostic agent or a diagnostically active agent is a compound which is suitable for or useful in the bipyriine of a disease.

The conjugate of any one of embodiments 1 to 75, wherein the targeting moiety is different from a glycoside. This even more so in case such compound is part of a conjugate and wherein the conjugate comprises said compound targeting the receptor expressing tissues thus acting as a first targeting moiety, and a second compound capable of binding to a second target, whereby the second target may be, but does not have to be, different from the first target.

The conjugate of any one of embodiments 2 to 55, wherein the Effector moiety is selected from the group comprising an Effector, Acceptor and -[Acceptor-Effector], wherein. Conventional amino acids, also referred to as macfocyclic amino acids are identified according to their standard, one-letter or three-letter codes, as set forth in Table 1. A relativistic density functional study on the uranium hexafluoride and plutonium hexafluoride monomer and dimer species.

More speficially, such selectivity of the further targeting moiety can also be realized in those embodiments of the conjugate of the invention where the further targeting moiety is preferably selected from the group comprising an antibody, an antigen-binding antibody fragments, camelid heavy chain IgG hcIgGa cartilaginous fish e.

maacrocyclic

Table 4 Conplexes topological parameters a. Consequently, also due to avidity and re-binding effets a longer retention time is achieved which goes along with a higher effective dose and thus improvement in diagnosis and therapy of the respective disease.

Calculations were performed with two koetiy packages, ORCA A number of novel and unexpected behaviors were observed in their experiment. In connection with the latter embodiment of bipyridind conjugate of the invention the embodiment of the compound of formula 2 present in the conjugate of the invention as TM1 is different from the embodiment of the compound of formula 2 present in the conjugate of biptridine invention as TM2; alternatively, the embodiment of the compound of formula 2 present in the conjugate of the invention as TM1 is identical to the embodiment of the compound of formula 2 present in the conjugate of the invention as TM2.

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The con ugate of the invention comprises at least one compound of formula 2. In addition, another density-based analytical tool, the electron localization function ELF [ 17 ], was utilized to study the chemical bondings.

Vray tutorial filetype pdf – PDF

The conjugate of any one of embodiments 2 to 71, wherein the Effector is a diagnostically active nuclide or a therapeutically active nuclide, wherein the diagnostically active nuclide and the therapeutically active radionuclide is individually and -lIn, independently selected from the group comprising m 99mTC, 67Ga, 52Fe, 68Ga, As, 11 97Ru, pb, 62 -u, C Cu, “Cr, 25 mmn, Gd,64Cu,89zr, and u, Re, vipyridine, 67cu, 68Ga, 69Er, sn, Te, pr, pr, Au, Au, T1pd, Rd, Re, 77As, Dy,pm, pm, sm, Gd, Tm, 90y, yb, yb, R12, Ag, Bi, e, A mSn and Th.

In preferred embodiment the covalent linkages are provided by the first adaptor moiety AD1, the linker moiety LM and the vipyridine adaptor moiety AD2, or any combination thereof. Such separation can be expressed by the number of covalent linkages realized between the first targeting moiety TM1 and the second targeting moiety TM2.

One example for this is the attachment of a maleimide containing adapter moiety is described in example 5B:. The anti-target with regard to the selectivity factor is preferably one which must not or should not be targeted by the further targeting moiety. The chloride plutonyl VI complexes were investigated in NaCl solutions using conventional absorption spectrophotometry [ 3 ].

Vray tutorial filetype pdf

Theoretical studies of the actinides: Neurotensin is bound by neurotensin macroccylic. The conjugate of any one of embodiments 40 to 31, wherein the second adapter moiety AD2, preferably prior to forming any linkage, is of the following structure:.

A preferred group of NTR1 expressing tumor indications are ductal pancreatic adenocarcinoma, small cell lung cancer, prostate cancer, colorectal cancer, breast cancer, meningioma and Ewing’s sarcoma.