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Mov Disord. Dec;20(12) International Cooperative Ataxia Rating Scale (ICARS): appropriate for studies of Friedreich’s ataxia? Cano SJ(1). The International Cooperative Ataxia Rating Scale (ICARS) is an outcome measure that was created in by the Committee of the World Federation of. INTERNATIONAL CO-OPERATIVE ATAXIA RATING SCALE. I: POSTURE AND GAIT DISTURBANCE. SCORE: 1. WALKING. CAPACITIES observed during a 10 .

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Certainly, more detailed psychometric ataxia, and this strategy alone may account for its limited evaluations of the ICARS in larger samples are urgently psychometric performance. The content on or accessible through Physiopedia is for informational purposes only.

Patients were assessed by the same clinician method, in measurement terms, of grouping the 19 items.

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Approaches to therapeutic angiogenesis for ischemic heart disease. Evaluating neurological out- ;2: Diagnostic criteria for multiple sclerosis: The ICARS has been validated for use in patients with focal cerebellar lesions [1] and hereditary spinocerebellar and Friedrich’s ataxia. To test for internal consistency, correlations of items within subscales and also between subscales were calculated using standard least squares linear regression.

Also, despite the fact that for MICONOS disease duration was derived from age at diagnosis and thus might underestimate disease duration, taaxia rate was comparable with the other centres.


A study of four rating scales. In this respect, the descriptive analysis of the dynamic ranges including floor and ceiling effects of the ICARS subscales and items, as described in this study, will be an important consideration in defining patient inclusion criteria. All psychometric analyses are acceptable, reliable, and valid indicators of ataxia se- except test—retest analyses were carried out on data pro- verity.

The average item-own-remainder correlation coefficient was 0. No correlation was seen after 20 years of disease progression Fig.

Scale for the Assessment and Rating of Ataxia (SARA) – Physiopedia

Mean values are indicated as dashed lines. Although total ICARS fulfils basic criteria for summated rating scales Spector,the grouping of items in subscales in the current version of the scale appears more problematic.

ICARS is a neurologist-completed rating scale devel- Gene-focused technologies have led to new treatments oped to assess the symptoms of ataxia. However, there are still only limited data available to establish reference values for disease progression. Inter-rater reliability and validity of two ataxia rating scales in children with brain tumours Heather HartleyBarry L. For Permissions, please email: A phase 3, double-blind, placebo-controlled trial of idebenone in Friedreich ataxia.

In addition, correlations between all subscales and also between all individual items were analysed. Physiopedia is not a substitute for professional advice or expert medical services from a qualified healthcare provider. Nunnally J, Bernstein I. Thomas Klockgether The Lancet. Such modifications are supported in our study by the data on the item—subscale correlations, the relative sensitivity to ceiling effects and the dynamic range of the items constituting the respective posture and gait disturbances and kinetic functions subscales.


In most cases Physiopedia articles icasr a secondary source and so should not be used as references.

International Cooperative Ataxia Rating Scale

Reliability and validity of the scale for the assessment and rating of ataxia: By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy PolicyTerms of Serviceand Dataset License. Sign In or Create an Account.

Qual Life Res 7. Figure 2 and Table 1 show ifars results for two groups of patients with a chosen cut-off of 14 years.

Expanding view of phenotype and oxidative stress in Friedreich’s ataxia patients with and without idebenone. MIG Th1 chemokine in Vitiligo. These findings are consistent with the aforementioned floor and ceiling effects, for which the same three items matched better with the respective other subscale.