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Hydrotropic Solubilization. Priyanka Arjaria1, Manoj Goyal2, Suman Jain3. 1Shri Ram College of pharmacy,Banmore,Morena, India, 2IPS College of pharmacy. Purpose. This study examines the mechanism of hydrotropic solubilization using the riboflavin-nicotinamide system. The most commonly proposed mechanism. On the other hand, planarity of the hydrophobic part has been emphasized as an important factor in the mechanism of hydrotropic solubilization. Solute consists.

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Formulation plays a prominent role and holds several benefits in drug discovery and development. View at Google Scholar. Journal of Pharmacy Research ; 3 3: The solutions were filtered through Whatman filter paper No. Hydrotropic solubilization is one such method [ 1 ].

This method could preclude the use of costly solvents in analysis. Application of mixed- hydrotropy to develop injection dosage forms of poorly water-soluble drugs.

The key objective of current research work was to enhance aqueous solubility solubilizarion this drug using hydrotropic solubilization technique. New spectroscopic determination of nifedipine using hydrotropic Solubilization.

Hydrotrope – Wikipedia

Studies on solubilization, formulation and evaluation of some drugs, Dept. This is an open access paper distributed under the copyright agreement with Serials Publication, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. SD was evaluated for dissolution rate and a marked increase in dissolution rate was observed with SD. This page was last edited on 27 Novemberat The type of anion or metal ion appeared to have a minor effect on the phenomenon[2].


It is used in muscular, skeletal, and joint disorders such as osteoarthritis and hydrotropjc arthritis. Maheshwari et al[10]; enhanced the aqueous solubility of paracetamol, a poorly water-soluble drug by use of concentrated solution of urea a hydrotropic agent.


The anionic group is involved in bringing about high aqueous solubility, which is a prerequisite for a hydrotropic substance.

Formerly, several techniques have been developed to enhance the aqueous solubility of poorly water-soluble drugs such as complexation, cosolvency, emulsions, liposomes, particle size reduction, solid state alteration, solid dispersions, prodrugs, salt formation, polymeric micelles, etc. Consider where is the amount of drug found before addition of pure drug, is the amount of drug found after addition of pure drug, and is the amount of pure drug added.

Quantitative analysis of theophylline bulk sample using sodium salicylate hydrotrope. Lornoxicam is a selective cyclooxygenase-1 and cyclooxygenase-2 inhibitor that exhibits anti-inflammatory, analgesic, and antipyretic activities.

It is also used in the treatment of other painful conditions including hydrorropic pain and primary dysmenorrhoea. Council of Science and TechnologyBhopal for funding this project work.

However, the term has been used in the literature to designate non-micelle-forming substances, either liquids or solids, organic or inorganic, capable of solubilizing insoluble compounds.

Sodium benzoate is cheaper than most of the organic solvents and thus may be a better substitute for expensive organic solvents that are used in routine analysis of pharmaceuticals. Sharma[25] were investigate that hydrotropic solution of 8M urea has been employed as hydrotroppic agent to solubilization poorly water soluble drug Pseudoephedrine Sulphate, Desloratidine, from fine powder of its tablet dosage form for spectrophotometric determination in ultraviolet region.

Physical Pharmacy, New Delhi, B.

Article Information

Preparation of Calibration Curve of Lumefantrine in 0. The absorbances were recorded against respective reagent blanks at appropriate wavelengths. Hydrotropes are a class of chemical hyrotropic which affect an increased aqueous solubility by several folds to certain solutes which are sparingly soluble in water under normal oslubilization.


Indian Pharmacist ; 5: Hydrotropy is a solubilization phenomenon whereby addition of large amount of second solute results in an increase in the aqueous solubility of another solute. Journal of Applied Chemical Research ; However, many hydrotropes do not seem to self-aggregate at all, unless a solubilisate has been added. For example sodium benzoate, urea, sodium salicylate and ibuprofen sodium etc.

Analysis of bulk sample of salicylic acid by application of hydrotropic solubilizationmethod.

Hydrotropic solubilization of poorly water-soluble drugs.

Article Information Sr No: From the above solution 1, 2, 3, 4, 5 and 6 ml was taken and diluted upto 10ml with 0. Hydrotropic solubilization technique to challenge the solubility of poorly water soluble drug valsartan. Lornoxicam is practically insoluble in water but soluble in alkaline solutions. A simple spectrophotometric estimation of Ketoprofen in tablets using mixed hydrotropy. Effect of a mixture of caffeine and nicotinamide on the solubility of vitamin B 2 in aqueous solution.

Solubility indicates the maximum amount of a substance that can be dissolved in a solvent at a given temperature. From Wikipedia, the free encyclopedia. Enhanced solubility study of sulphasalazine using different solubilization techniques.

LOD and LOQ were calculated as andrespectively, where is the slope of the calibration curve and is the standard deviation of response [ 10 ].